Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-kappaB activation, IkappaBalpha degradation, and the expression of MCP-1, TGF-beta1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-kappaB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis[1][2][3][4].
Molecular Weight:
248.322
Purity:
99.77
CAS Number:
[68370-47-8]
Formula:
C15H20O3
Target:
Akt,NF-kappaB,PI3K,TGF-beta/Smad
Application Notes:
Natural Products
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