Deoxyandrographolide is an orally active lactone found in the Andrographis paniculata Nees. Deoxyandrographolide shows a KD of 38.4 µM of HDAC1. Deoxyandrographolide enhances GLUT4 plasma membrane translocation, activates PI3K and AMPK-dependent signaling pathways, suppresses fasting blood glucose, serum insulin, triglycerides, and LDL-cholesterol levels. Deoxyandrographolide enhances HDAC1 expression via inhibited ubiquitination degradation, represses H3K4me3, improves chromosome stability, and restrains aging biomarkers p16, p21, gammaH2A.X, p53 and ROS production. Deoxyandrographolide interacts with Foot-and-Mouth Disease Virus 3Cpro active site, inhibits protease and IFN-antagonist activity, derepresses ISG expression, and inhibits viral replication. Deoxyandrographolide can be used for the researches of type 2 diabetes mellitus, vascular senescence and virus infection[3].
Molecular Weight:
334.45
Purity:
99.87
CAS Number:
[79233-15-1]
Formula:
C20H30O4
Target:
Akt,AMPK,GLUT,HDAC,Histone Demethylase,IFNAR,MDM-2/p53,PI3K,Reactive Oxygen Species (ROS),Virus Protease
Application Notes:
MCE Product type: Natural Products
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