Artepillin C is an orally active CREB/CRTC2 inhibitor and TRPA1 covalent agonist (EC50=1.8 µM). Artepillin C inhibits CREB/CRTC2-mediated gene transcription and downregulates BMAL1 expression to regulate glucose and lipid metabolism. Artepillin C can also activate TRPA1 channels to induce spicy taste signals. Artepillin C can inhibit tumor cell proliferation, induce necroptosis, improve insulin resistance and inhibit liver lipid synthesis. Artepillin C can be used in the study of metabolic syndrome, tumor prevention and treatment, and inflammation[1][2][3][4].
Molecular Weight:
300.39
Purity:
98.28
CAS Number:
[72944-19-5]
Formula:
C19H24O3
Target:
Epigenetic Reader Domain,Necroptosis,TRP Channel
Application Notes:
MCE Product type: Natural Products
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