Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC50s of 2.9 µM (CYP2B6), 9.2 µM (CYP2C9), 11,2 µM (CYP2C19) and >30 µM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD50 value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis[1][2][3][4][5][6].
Molecular Weight:
246.30
Purity:
99.61
CAS Number:
[7727-79-9]
Formula:
C15H18O3
Target:
Bacterial,mTOR,Ribosomal S6 Kinase (RSK)
Application Notes:
MCE Product type: Natural Products
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