COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC50 = 18 µg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model[1].
Molecular Weight:
242.23
CAS Number:
[57449-30-6]
Formula:
C11H14O6
Target:
Glyoxalase (GLO)
Application Notes:
Natural Products
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