Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC50 of 4.2 µM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-kappaB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-kappaB nuclear translocation. Pestanoid A can be used for the study of osteoporosis[1].
Molecular Weight:
362.42
Formula:
C20H26O6
Target:
ERK,JNK,p38 MAPK
Application Notes:
MCE Product type: Natural Products
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