MO-2097 is a RAF-1/HIF-1alpha inhibitor. MO-2097 induces RAF-1 destabilization, leading to a reduction in EMT-associated transcription factors and mesenchymal markers. MO-2097 inhibits HIF-1a protein expression mediated by hnRNPA2B1 under hypoxic and mimetic hypoxia. MO-2097 induces mitochondrial ROS, which leads to apoptosis in cells. MO-2097 effectively suppresses colorectal cancer metastasis by inhibiting the RAF/MEK/ERK signaling pathway. MO-2097 attenuates tumor growth in a xenograft HCT116 cell mouse model. MO-2097 can be used for the study of colorectal cancer[1][2].
Molecular Weight:
308.33
CAS Number:
[2744300-63-6]
Formula:
C19H16O4
Target:
Apoptosis,Caspase,ERK,HIF/HIF Prolyl-Hydroxylase,MEK,Raf,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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