Naamidine J, CAS [[2227550-73-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-N14001
Supplier Catalog Number:
HY-N14001
Alternative Catalog Number:
MCE-HY-N14001-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Naamidine J is an imidazole-type alkaloids discovered in a sponge. Naamidine J inhibits inflammation by binding to the protein CSE1L (KD = 5.41 µM). Namidine J significantly inhibits the expression of pro-inflammatory factors such as TNF-alpha, IL-1beta, and IL-6, and upregulates anti-inflammatory factors such as CD206 and Arg-1. Namidine J inhibits PD-L1 and shows antitumor activity. Namidine J significantly reduces pulmonary tissue edema, inflammatory cell infiltration and cytokine storm in mice. Namidine J can be used for the research on the immune microenvironment of acute lung injury and tumors[1][2].
