4-Isovalerylspiramycin I, CAS [[267662-22-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-N15249
Supplier Catalog Number:
HY-N15249
Alternative Catalog Number:
MCE-HY-N15249-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
Isovalerylspiramycin I, Shengjimycin E
4-Isovalerylspiramycin I (Isovalerylspiramycin I) is a topoisomerase 1 (TOP1) inhibitor and an antitumor agent. 4-Isovalerylspiramycin I directly binds to TOP1, suppresses DNA replication, and induces DNA damage. 4-Isovalerylspiramycin I downregulates phosphorylated CHEK1 and the ATR/CHEK1 DNA damage repair pathway, blocks DNA repair, and augments DNA damage. 4-Isovalerylspiramycin I suppresses proliferation, migration, and invasion of osteosarcoma cells. 4-Isovalerylspiramycin I induces apoptosis and cell cycle arrest in osteosarcoma cells. 4-Isovalerylspiramycin I exerts antibacterial activity against methicillin-resistant Staphylococcus aureus. 4-Isovalerylspiramycin I can be used for the research of osteosarcoma, upper respiratory bacterial infections, and methicillin-resistant Staphylococcus aureus infection[1][2].
