Azaspirene ((-)-Azaspirene) is an angiogenesis and Raf-1 activation inhibitor isolated from the fungus Neosartorya sp. Azaspirene inhibits vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cell (HUVEC) migration and Raf-1 activation, but has no effect on the activation of kinase insert domain-containing receptor/fetal liver kinase 1 (VEGF receptor 2)[1].
Molecular Weight:
369.41
CAS Number:
[461644-34-8]
Formula:
C21H23NO5
Target:
Raf,VEGFR
Application Notes:
MCE Product type: Natural Products
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