Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142)[1].
Molecular Weight:
306.35
CAS Number:
[10092-04-3]
Formula:
C17H22O5
Target:
P-glycoprotein
Application Notes:
MCE Product type: Natural Products
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