Halofuginone (hydrochloride), CAS [[1217623-74-9]]
Biozol Catalog Number:
MCE-HY-N1584B
Supplier Catalog Number:
HY-N1584B
Alternative Catalog Number:
MCE-HY-N1584B-1MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
RU-19110 (hydrochloride)
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-beta activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[1][2][3][4][5].
