3,4-Dihydroxyacetophenone (3,4-DHAP) is a phenolic compound with oral bioavailability, possessing potent antioxidant, anti-inflammatory, anticancer and cardiovascular protective activities. 3,4-Dihydroxyacetophenone inhibits mushroom Tyrosinase activity with an IC50 of 10 µM, thereby suppressing melanogenesis. 3,4-Dihydroxyacetophenone inhibits platelet aggregation in platelet-rich plasma. 3,4-Dihydroxyacetophenone reduces ROS levels in human umbilical vein endothelial cells treated with high glucose, upregulates the expression of Nrf2, HO-1 and PARP-1 in cells, and promotes the nuclear translocation of Nrf2. 3,4-Dihydroxyacetophenone induces autophagy and apoptosis. 3,4-Dihydroxyacetophenone inhibits seed germination/growth in most plants. 3,4-Dihydroxyacetophenone can be used in the research of cancer, neurodegenerative diseases, non-alcoholic steatohepatitis, diabetes, obesity, skin pigmentation disorders, and cardiovascular and cerebrovascular diseases[1][2][3][4][5][6].
Molecular Weight:
152.15
Purity:
99.96
CAS Number:
[1197-09-7]
Formula:
C8H8O3
Target:
Apoptosis,Autophagy,Keap1-Nrf2,PARP,Reactive Oxygen Species (ROS),Tyrosinase
Application Notes:
MCE Product type: Natural Products
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