Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 µM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, alpha-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinsons disease. Tambulin can be used for the researches of Parkinsons disease, lung squamous cell carcinoma, and diabetes[1][2][3][4][5].
Molecular Weight:
344.32
CAS Number:
[571-72-2]
Formula:
C18H16O7
Target:
Apoptosis,Bcl-2 Family,Caspase,Reactive Oxygen Species (ROS),Succinate Dehydrogenase,alpha-synuclein
Application Notes:
MCE Product type: Natural Products
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