Butrin is a compound found in Butea monosperma flowers. Butrin reduces expression of SIRT1, AURKB, cyclin D1, pAKT, GSK-3beta, beta-catenin, and TGF-3beta expression, enhances apoptosis and ROS production in cancer cells. Butrin downregulates Wnt and NF-kappaB signaling, mitigates oxidative stress, reduces proinflammatory cytokine (TNF-alpha, IL-6 and IL-8) production and suppresses neuroinflammation. Butrin inhibits IKK enzyme activity. Butrin can be used for the researches of colorectal cancer, Alzheimers disease, and rheumatoid arthritis[1][2][3].
Molecular Weight:
596.53
CAS Number:
[492-13-7]
Formula:
C27H32O15
Target:
Akt,Apoptosis,Aurora Kinase,GSK-3,IKK,Interleukin Related,NF-kappaB,Reactive Oxygen Species (ROS),Sirtuin,TGF-beta Receptor,TNF Receptor,Wnt,beta-catenin
Application Notes:
MCE Product type: Natural Products
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