Bulbocapnine is an aporphine isoquinoline alkaloid that exerts antagonistic effects on dopamine Receptor) and alpha-adrenergic receptors, as well as anti-peroxidative effects. The Ki value of bulbocapnine for tyrosine hydroxylase (TH) is 0.20 mM. Bulbocapnine reduces intracellular dopamine content, inhibits TH activity, and decreases Ca2+ concentration. Bulbocapnine antagonizes the dose-dependent inhibitory effect of dopamine on the heart rate acceleration induced by stimulating the postganglionic fibers of the right cardiac accelerator nerve[1][2].
Molecular Weight:
325.36
CAS Number:
[298-45-3]
Formula:
C19H19NO4
Target:
Adrenergic Receptor,Dopamine Receptor
Application Notes:
MCE Product type: Natural Products
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