Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape[1][2][3][4].
Molecular Weight:
530.52
Purity:
99.30
CAS Number:
[56725-99-6]
Formula:
C27H30O11
Target:
Apoptosis,Aryl Hydrocarbon Receptor,Bcl-2 Family,Caspase,CDK,IFNAR,JAK,NOD-like Receptor (NLR),PD-1/PD-L1,Reactive Oxygen Species (ROS),STAT
Application Notes:
MCE Product type: Natural Products
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