5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 µM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 µM[1].
Molecular Weight:
388.37
Purity:
99.91
CAS Number:
[2174-59-6]
Formula:
C20H20O8
Target:
Leukotriene Receptor,Lipoxygenase
Application Notes:
MCE Product type: Natural Products
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