5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRalpha and PPARgamma mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinsons disease, type 2 diabetes mellitus and pathogenic fungal infection[1][2][3].
Molecular Weight:
178.14
Purity:
99.94
CAS Number:
[31721-94-5]
Formula:
C9H6O4
Target:
Caspase,Fungal,Keap1-Nrf2,PARP
Application Notes:
MCE Product type: Natural Products
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