Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, caspase-3, -7, -9, upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic Bcl-2 and Bcl-XL. Caudatin suppresses VEGF, FAK phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARalpha/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimers disease[1][2][3][4].
Molecular Weight:
490.63
Purity:
99.95
CAS Number:
[38395-02-7]
Formula:
C28H42O7
Target:
Apoptosis,Autophagy,Bcl-2 Family,Caspase,FAK,JNK,Mitochondrial Metabolism,p38 MAPK,PARP,PPAR,Reactive Oxygen Species (ROS),VEGFR,WDR5
Application Notes:
MCE Product type: Natural Products
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