Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IkappaB and NF-kappaB (p65), blocks nuclear translocation of NF-kappaB (p65) and decreases mRNA levels of IkappaBalpha and TNF-alpha[1].
Molecular Weight:
520.70
Purity:
99.74
CAS Number:
[50298-90-3]
Formula:
C30H48O7
Target:
Apoptosis
Application Notes:
MCE Product type: Natural Products
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