Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-beta/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis[1][2][3][4][5].
Molecular Weight:
293.27
Purity:
99.44
CAS Number:
[13395-02-3]
Formula:
C17H11NO4
Target:
Aquaporin,Cadherin,Drug Metabolite,TGF-beta/Smad
Application Notes:
MCE Product type: Natural Products
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