Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 µM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1beta-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases[1][2][3][4][5][6].
Molecular Weight:
307.77
Purity:
99.52
CAS Number:
[11041-94-4]
Formula:
C16H18ClNO3
Target:
Apoptosis,MAP3K,MDM-2/p53,ROS Kinase
Application Notes:
Natural Products
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