Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 µg/mL. Yamogenin can be studied in research on gastric cancer[1][2].
Molecular Weight:
414.62
Purity:
99.86
CAS Number:
[512-06-1]
Formula:
C27H42O3
Target:
Apoptosis,Fatty Acid Synthase (FASN),LXR,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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