Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-kappaB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant alpha-synuclein and huntingtin. Onjisaponin B reduces beta-amyloid (Abeta) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB[1][2][3][4].
