Flavokawain B (Flavokavain B) is an orally active chalcone. Flavokawain B results in activation of caspase-9, -3 and -8, cleavage of PARP. Flavokawain B down-regulates Bcl-2 with concomitant increase in Bax level. Flavokawain B inhibits NF-kappaB, PI3K/Akt and MAPK signaling pathway. Flavokawain B exhibits Apoptotic effects. Flavokawain B inhibits MMP-9 and promotes ROS generation. Flavokawain B inhibits multiple tumors and inflammation[1][2][3][4][5][6][7][8][9][10][11][12][13].
Molecular Weight:
284.31
Purity:
99.99
CAS Number:
[1775-97-9]
Formula:
C17H16O4
Target:
Akt,Apoptosis,Bcl-2 Family,Caspase,MMP,NF-kappaB,p38 MAPK,PARP,PI3K,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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