Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the alpha7-nAChR with an IC50 of 19.1 µM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-kappaB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation. Crebanine inhibits voltage-dependent Na+ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimers disease[1][2][3][4][5][6].
Molecular Weight:
339.39
Purity:
99.83
CAS Number:
[25127-29-1]
Formula:
C20H21NO4
Target:
Akt,Apoptosis,Bacterial,ERK,Interleukin Related,nAChR,NF-kappaB,NO Synthase,p38 MAPK,Reactive Oxygen Species (ROS),TNF Receptor
Application Notes:
Natural Products
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