Arecaidine is a GABA transport system inhibitor. Arecaidine inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-beta and TNF-alpha in cells, downregulates the expression of PPAR-gamma and PCK1 in cells, and upregulates the expression of TGF-beta1. Arecaidine inhibits the uptake of gamma-aminobutyric acid and beta-alanine by the central nervous system of cats. Arecaidine inhibits hPAT1-mediated L-[3H]proline uptake in cells. Arecaidine can be used in research related to neurological diseases[1][2][3].
