9-Methyl salvianolate B (MSB) is a blood-brain barrier-permeable inhibitor with high affinity for g5Rp, with a Kd value of 117 nM against African swine fever virus (ASFV) g5Rp. 9-Methyl salvianolate B also acts as a ZBP1 inhibitor. It exhibits strong binding affinity to key proteins in the PPARgamma/NF-kappaB pathway. 9-Methyl salvianolate B blocks the interaction between ASFV g5Rp and host proteins eIF5A or RPS15. It restores hypusination modification of eIF5A, promotes autophagy (Autophagy), and inhibits ASFV replication. 9-Methyl salvianolate B effectively disrupts ZBP1-mediated PANoptosome assembly. It effectively alleviates myocardial ischemia/reperfusion injury. 9-Methyl salvianolate B can be used in studies related to African swine fever[1][2][3].
Molecular Weight:
732.64
Purity:
99.54
CAS Number:
[1167424-31-8]
Formula:
C37H32O16
Target:
Autophagy,DNA/RNA Synthesis,NF-kappaB,PPAR
Application Notes:
MCE Product type: Natural Products
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