Gomisin D is an orally active lignan that binds to PDGFRbeta with a Kd of 10 µM. By targeting PDGFRbeta to regulate signaling pathways, Gomisin D inhibits the activation and proliferation of hepatic stellate cells and promotes their apoptosis, thereby ameliorating hepatic fibrosis. Gomisin D exhibits multiple activities such as photoprotection, antimelanogenesis, antioxidant effects, and hypoglycemic activity. Gomisin D can be used in studies related to diabetes, Alzheimers disease, and hepatic fibrosis[1][2][3].
Molecular Weight:
530.56
Purity:
99.56
CAS Number:
[60546-10-3]
Formula:
C28H34O10
Target:
Akt,Apoptosis,COX,ERK,Interleukin Related,p38 MAPK,PDGFR,Reactive Oxygen Species (ROS),Tyrosinase,UGT
Application Notes:
MCE Product type: Natural Products
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