Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis[1][2][3].
Molecular Weight:
390.51
Purity:
99.70
CAS Number:
[514-39-6]
Formula:
C23H34O5
Target:
Caspase,Interleukin Related,Necroptosis,NOD-like Receptor (NLR),Pyroptosis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
* VAT and and shipping costs not included. Errors and price changes excepted
