Taccalonolide A, a steroid found in Tacca chantrieri, is a microtubule stabilizer. Taccalonolide A promotes tubulin polymerization, stabilizes microtubules, and shows little cross-resistance with Paclitaxel (HY-B0015) in cell lines with beta-tubulin Paclitaxel-binding region mutations. Taccalonolide A is transported less efficiently by P-glycoprotein. Taccalonolide A induces increased cellular microtubule density, thick interphase microtubule bundles, abnormal multipolar mitotic spindles, G2-M phase cell cycle accumulation, Bcl-2 phosphorylation, and apoptosis. Taccalonolide A inhibits cell proliferation in drug-sensitive and multidrug-resistant cell lines. Taccalonolide A has cytotoxic and antimalarial activities. Taccalonolide A can be used for the researches of ovarian cancer and infection[1][2].
