Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3].
Molecular Weight:
702.74
Purity:
99.29
CAS Number:
[108885-68-3]
Formula:
C36H46O14
Target:
Apoptosis,Microtubule/Tubulin
Application Notes:
MCE Product type: Natural Products
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