Diphyllin is an orally active V-ATPase inhibitor (IC50=17 nM) and HIV-1 inhibitor (IC50=0.38 µM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC50=0.6 nM for acid influx inhibition), thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption[1][2][3][4].
Molecular Weight:
380.35
Purity:
99.83
CAS Number:
[22055-22-7]
Formula:
C21H16O7
Target:
HIV,Influenza Virus,Proton Pump,VSV
Application Notes:
MCE Product type: Natural Products
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