Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC50=0.74 µM, Ki=0.26 µM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer[1][2][3][4].
Molecular Weight:
230.26
Purity:
99.15
CAS Number:
[484-14-0]
Formula:
C14H14O3
Target:
Akt,Apoptosis,Monoamine Oxidase,PI3K
Application Notes:
MCE Product type: Natural Products
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