Isorhapontigenin (Standard), CAS [[32507-66-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-N2593R
Supplier Catalog Number:
HY-N2593R
Alternative Catalog Number:
MCE-HY-N2593R-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Isorhapontigenin (Standard) is the analytical standard of Isorhapontigenin (HY-N2593). This product is intended for research and analytical applications. Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-alpha, PGC-1alpha and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation, it inhibits tumor growth, cell invasion, NF-kappaB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation, it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes.
Molecular Weight:
258.27
CAS Number:
[32507-66-7]
Formula:
C15H14O4
Target:
Akt,Apoptosis,Autophagy,Keap1-Nrf2,MMP,NF-kappaB,PI3K,Reactive Oxygen Species (ROS),Reference Standards
Application Notes:
MCE Product type: Reference Standards
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