Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer[1].
Molecular Weight:
482.69
Purity:
99
CAS Number:
[465-18-9]
Formula:
C31H46O4
Target:
Akt,Apoptosis,Caspase,JNK,MDM-2/p53,PARP,PTEN
Application Notes:
MCE Product type: Natural Products
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