Dammarenediol II is a ginsenoside precursor. Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3beta. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy[1][2].
Molecular Weight:
444.73
Purity:
99.81
CAS Number:
[14351-29-2]
Formula:
C30H52O2
Target:
Akt,Apoptosis,GSK-3,MDM-2/p53,mTOR,OGT,PARP,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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