Eriodictyol-7-O-glucoside (Eriodictyol 7-O-beta-D-glucoside), a flavonoid, is an Nrf2 activator. Eriodictyol-7-O-glucoside exhibits significant scavenging effects on both hydroxyl radicals and superoxide anions, with IC50 values of 0.28 mM and 0.30 mM, respectively. Eriodictyol-7-O-glucoside increases the nuclear localization of Nrf2 and induces the expression of the Nrf2/ARE-dependent genes. Eriodictyol-7-O-glucoside provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. Eriodictyol-7-O-glucoside demonstrates neuroprotective efficacy in a rat model of focal cerebral ischemia (MCAO). Eriodictyol-7-O-glucoside can be used for the study of stroke[1][2][3].
Molecular Weight:
450.39
Purity:
99.80
CAS Number:
[38965-51-4]
Formula:
C21H22O11
Target:
Keap1-Nrf2
Application Notes:
MCE Product type: Natural Products
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