Humantenine is a highly toxic indole alkaloid from Gelsemium elegans(Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD50 values of Humantenine are [1][2][3][5].
Molecular Weight:
354.44
Purity:
98
CAS Number:
[82375-29-9]
Formula:
C21H26N2O3
Target:
Anaplastic lymphoma kinase (ALK),METTL3
Application Notes:
MCE Product type: Natural Products
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