Licoflavone C is a broad-spectrum antiviral inhibitor with estrogen-like properties. Licoflavone C binds to viral endonuclease (CEN) and inhibits the replication of various bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV) and lymphocytic choriomeningitis virus in a non-substrate competitive manner. The IC50 values of Licoflavone C against SFTSV CEN and SFTSV CEN are 35.5 µM and 135.8 µM, respectively, and its Kd value against SFTSV CEN is 9.53 µM. After viral entry into cells, Licoflavone C reduces viral loads in mouse tissues in a dose-dependent manner, and exhibits extremely low cytotoxicity and genotoxicity. Licoflavone C induces cell apoptosis (apoptosis) by increasing caspase 3/7 activity, blocks the cell cycle, and alleviates chemotherapy-induced chromosomal damage. Licoflavone C is applicable to the research on severe fever with thrombocytopenia syndrome and related viral infection mechanisms[1][2][3].
Molecular Weight:
338.35
Purity:
99.83
CAS Number:
[72357-31-4]
Formula:
C20H18O5
Target:
Apoptosis,Caspase,Estrogen Receptor/ERR
Application Notes:
MCE Product type: Natural Products
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