Isocucurbitacin B is a natural terpenoid compound extracted from Pedicellus Melo. Isocucurbitacin B can inhibit the PI3K/AKT, MAPK, and STAT3 signaling pathways and downregulate CAV1 expression. Isocucurbitacin B can inhbit cancer cell proliferation, migration and invision. Isocucurbitacin B can induce apoptosis and cause G2/M phase arrest. Isocucurbitacin B can decrease intracellular cholesterol and PH levels and increase intracellular calcium levels. Isocucurbitacin B can be used for the research of cancer, such as glioma[1][2].
Molecular Weight:
558.70
CAS Number:
[17278-28-3]
Formula:
C32H46O8
Target:
Akt,Apoptosis,p38 MAPK,PI3K,STAT
Application Notes:
MCE Product type: Natural Products
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