Bacopaside I is an orally effective aquaporin AQP1 inhibitor and PKC modulator with neuroprotective and anticancer activities. Bacopaside I specifically blocks the water channel and cGMP-gated ion channel activities of AQP1 without affecting AQP4, thereby inhibiting the migration of colon cancer cells expressing AQP1. Bacopaside I activates the Akt pathway by interacting with PI3K, specifically inhibits MAO-A, effectively alleviates neuron necrosis and apoptosis induced by oxygen-glucose deprivation, reduces oxidative stress, and regulates the surface expression of neuroreceptors. When combined with Bacopaside II (HY-N6016), Bacopaside I significantly reduces the viability, proliferation and invasion ability of breast cancer cells, and binds to the pregnane X receptor (PXR). Bacopaside I is applicable to the research of colon cancer, breast cancer, vascular dementia, cerebral ischemia and other related diseases[1][2][3][4].
Molecular Weight:
979.13
Purity:
99.20
CAS Number:
[382148-47-2]
Formula:
C46H74O20S
Target:
Akt,Apoptosis,Aquaporin,Monoamine Oxidase,PI3K,PKC,Pregnane X Receptor (PXR)
Application Notes:
MCE Product type: Natural Products
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