Liensinine perchlorate is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine perchlorate suppresses autophagy and apoptosis, clears Abeta, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine perchlorate activates AMPK and inhibits the expression of HIF-1alpha and VEGF, thereby suppressing angiogenesis. Liensinine perchlorate exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine perchlorate can be used for the research of diseases such as Alzheimers disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke[1][2][3][4][5].
Purity:
99.67
CAS Number:
[2385-63-9]
Formula:
C37H42N2O6.xHClO4
Target:
Akt,Amyloid-beta,Apoptosis,Autophagy,HIF/HIF Prolyl-Hydroxylase,JAK,JNK,p38 MAPK,PI3K,Reactive Oxygen Species (ROS),STAT,VEGFR
Application Notes:
MCE Product type: Natural Products
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