Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-kappaB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression[1][2][3][4][5].
Molecular Weight:
343.50
Purity:
98
CAS Number:
[1354-84-3]
Formula:
C22H33NO2
Target:
Apoptosis,c-Myc,ERK,NF-kappaB,P2X Receptor,p38 MAPK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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