Galloylpaeoniflorin (6-O-Galloyl paeoniflorin) is an orally active galloylated derivative of Paeoniflorin (HY-N0293) found in peony roots with various anti-inflammatory and antioxidant activities. Galloylpaeoniflorin suppresses RANKL-induced activation of ERK, JNK, c-Fos, c-Jun, and NFATc1, and reduces osteoclast-specific gene expression. Galloylpaeoniflorin activates Nrf2 and PI3K/Akt pathways, inhibits NF-kappaB activation, and scavenges ROS to reduce oxidative DNA, lipid, and protein damage. Galloylpaeoniflorin attenuates neuroinflammation, inhibits apoptosis, reduces Helicobacter pylori-induced gastric mucosa injury and UVB-induced cell damage. Galloylpaeoniflorin can be used for the research of osteoporosis, gastritis, ischemic stroke and skin diseases[1][2][3][4][5].
Molecular Weight:
632.57
Purity:
98.30
CAS Number:
[122965-41-7]
Formula:
C30H32O15
Target:
Akt,Apoptosis,DNA/RNA Synthesis,ERK,JNK,Keap1-Nrf2,NF-kappaB,Nuclear Factor of activated T Cells (NFAT),PI3K,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Natural Products
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