Plantainoside D, a phenylethanoid glycosides, is a IKK-beta inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC50 of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-kappaB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension[1][2][3][4][5][6].
Molecular Weight:
640.59
Purity:
99.15
CAS Number:
[147331-98-4]
Formula:
C29H36O16
Target:
Angiotensin-converting Enzyme (ACE),Apoptosis,Calcium Channel,IKK,NF-kappaB,NOD-like Receptor (NLR),PKC,Reactive Oxygen Species (ROS),Sirtuin
Application Notes:
MCE Product type: Natural Products
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