Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3beta, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]
Molecular Weight:
1209.32
Purity:
99.95
CAS Number:
[66663-91-0]
Formula:
C57H92O27
Target:
Apoptosis,IAP
Application Notes:
MCE Product type: Natural Products
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