Rhein 8-O-beta-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-beta-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-beta1/Smad signaling. Rhein 8-O-beta-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-beta-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-beta-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection[1][2][3].
