Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase GOT1. Aspulvinone O inhibits glutamine metabolism and reduces NADPH production, thereby inducing oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O inhibits PDAC cell proliferation in vitro and tumor growth in xenograft models[1][2].
Molecular Weight:
448.51
Purity:
96
CAS Number:
[914071-54-8]
Formula:
C27H28O6
Target:
Aminotransferases (Transaminases) ,Apoptosis
Application Notes:
MCE Product type: Natural Products
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