K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene[3].
Molecular Weight:
467.47
Purity:
99.45
CAS Number:
[99533-80-9]
Formula:
C27H21N3O5
Target:
Antibiotic,Autophagy,CaMK,PKA,PKC,Trk Receptor
Application Notes:
MCE Product type: Natural Products
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